HORDB

ID: hor004664
Uniprot ID: Q8L9H6
Protein name: CLAVATA3/ESR (CLE)-related protein 17
Gene name: CLE17
Organism: Arabidopsis thaliana (Mouse-ear cress)
Family: CLV3/ESR signal peptide family
Source: Plant
Expression: [CLE17p]: Mostly expressed in seedlings, roots, flowers, stems and apex, and, to a lower extent, in leaves and siliques.
Disease: NA
Comments: NA
Taxonomy: Arabidopsis (genus), Camelineae (tribe), Brassicaceae (family), Brassicales (order), malvids, rosids, Pentapetalae, Gunneridae, eudicotyledons, Mesangiospermae, Magnoliopsida (class), Spermatophyta, Euphyllophyta, Tracheophyta, Embryophyta, Streptophytina (subphylum), Streptophyta (phylum), Viridiplantae (kingdom), Eukaryota (superkingdom), cellular organisms
GO MF: NA
GO BP: GO:0010078 maintenance of root meristem identity; GO:0010088 phloem development; GO:0030154 cell differentiation; GO:0045168 cell-cell signaling involved in cell fate commitment; GO:0045595 regulation of cell differentiation; GO:0048731 system development
GO CC: GO:0005576 extracellular region; GO:0048046 apoplast

Sequence: TMCFFLFFFVFYVSFQIVLSSSASVGYSRLHLVASPPPPPPRKALRYSTAPFRGPLSRDDIYGDDKRVVHTGPNPLHN
Length: 78(22-99)
Propeptide: MTHVLVRRQGQGKKRRWDVNMTMCFFLFFFVFYVSFQIVLSSSASVGYSRLHLVASPPPPPPRKALRYSTAPFRGPLSRDDIYGDDKRVVHTGPNPLHN
Signal peptide: MTHVLVRRQGQGKKRRWDVNM
Modification: T73 Hydroxyproline
Glycosylation: T73 O-linked (Ara...) hydroxyproline
Mutagenesis: NA

Function: Extracellular signal peptide that regulates cell fate. Represses root apical meristem maintenance.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor004664_AF2.pdb

hor004664_ESM.pdb

Mass:	1016068	Formula:	C409H611N107O106S2
Absent amino acids:	EW	Common amino acids:	PS
pI:	10	Basic residues:	11
Polar residues:	23	Hydrophobic residues:	28
Hydrophobicity:	-2.56	Boman Index:	-9614
Half-Life:	7.2 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	76.15
Instability Index:	4564.23	Extinction Coefficient cystines:	5960
Absorbance 280nm:	77.4

PubMed ID: 30114285
Title: The Signaling Peptide-Encoding Genes CLE16, CLE17 and CLE27 Are Dispensable for Arabidopsis Shoot Apical Meristem Activity